L'objectif de ce projet est d'explorer le concept ISA. L'investigation "Demonstration ISA" est simplement cela : la création d'une structure minimale ISA.
D'autre part je (Paulette) me suis aussi amusée à explorer les fonctionalités SEEK/ISA en copiant une partie du contenu de https://demo.fairdomhub.org/investigations/2, voir https://research-sharing.cesgo.org/investigations/58.
From https://fairdomhub.org/projects/75 : The SEEK is a web interface to a database of research "assets" organised in a hierarchical "ISA structure" (investigation-study-assay) [1]. These are further organised into projects and programmes.
- Programme = Overarching research theme (The Digital Salmon)
- Project = Research grant (DigiSal, GenoSysFat)
- Investigation = a particular biological process, phenomenon or thing (typically corresponds to [plans for] one or more closely related papers)
- Study = experiment whose design reflects a specific biological research question
- Assay = standardized measurement or diagnostic experiment using a specific protocol (applied to material from a study)
The main Asset types are
- Data file
- Model file
- Standard operating procedure (SOP)
A key benefit of the SEEK is that it provides context for research assets. Each asset's webpage has an interactive graph linking to related assets. Thus, simply sharing a link to an experiment (a Study) makes clear its purpose and broader motivation, shows the resulting data, and links to SOPs for method details.
SEEK ID: https://research-sharing.cesgo.org/projects/18
Public web page: https://www.france-bioinformatique.fr
Organisms: No Organisms specified
CesGO PALs: No PALs for this Project
Project created: 16th Jul 2020
Related items
Projects: Test_IFB, Training_private
Institutions: INRA
Projects: CeSGO project, Training, Rapsodyn, Test_IFB, Training_private
Institutions: GenOuest, Institut Français de Bioinformatique

Expertise: Data Management, Bioinformatics
Projects: Test_IFB
Institutions: Institut Français de Bioinformatique
Projects: Test_IFB
Institutions: Institut Français de Bioinformatique
Comme son nom l'indique, nous allons simplement créer une simple structure/ arbre ISA.
Submitter: Paulette Lieby
Studies: Example Study
Assays: Example Experimental Assay, Example Modelling Analysis
Snapshots: No snapshots
Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried... SEEK ID: https://demo.fairdomhub.org/investigations/2
Submitter: Paulette Lieby
Studies: A time course analysis of transcription response in yeast treated with r..., Glycolysis in Saccharomyces cerevisiae
Snapshots: No snapshots
From https://fairdomhub.org/studies/244?graph_view=tree
A Study corresponds to an experiment whose design reflects a specific biological research question. It is part of an Investigation into a particular process, phenomenon or thing. A Study will have Assays that are "measurement experiments", a standardized measurement or diagnostic experiment using a specific protocol, applied to material from a Study.
Submitter: Paulette Lieby
Investigation: Demonstration ISA
Assays: Example Experimental Assay, Example Modelling Analysis
Snapshots: No snapshots
Submitter: Paulette Lieby
Investigation: Growth control of the eukaryote cell: a systems...
Assays: No Assays
Snapshots: No snapshots
Submitter: Paulette Lieby
Investigation: Growth control of the eukaryote cell: a systems...
Snapshots: No snapshots
Submitter: Paulette Lieby
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Growth control of the eukaryote cell: a systems...
from https://fairdomhub.org/assays/521?graph_view=tree
An Experimental Assay is a standardized measurement or diagnostic experiment using a specific protocol, applied to material from a study. Examples include RNA sequencing, proteomics, metabolomics, and many others.
There are many Experimental Assay Types to choose from, as well as many Technology Type. Moreover, one can create new types in both cases.
Finally, note that one may also associate this assay with one or more organisms, add samples, ...
Submitter: Paulette Lieby
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Demonstration ISA
Study: Example Study
Organisms: No organisms
SOPs: E-coli extraction protocol
Data files: No Data files
Snapshots: No snapshots
An excellent example can be found https://demo.fairdomhub.org/assays/7?graph_view=tree which shows how a Model can be added to this analysis, together with a model that can be simulated on the fly on https://fair-dom.org/jws-online/.
I actually copy this here and one can run the model from there.
Submitter: Paulette Lieby
Biological problem addressed: Model Analysis Type
Investigation: Demonstration ISA
Study: Example Study
Organisms: No organisms
Models: Teusink
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Creators: None
Submitter: Paulette Lieby
Investigations: Growth control of the eukaryote cell: a systems...
Creator: Paulette Lieby
Submitter: Paulette Lieby
Model type: Not specified
Model format: SBML
Environment: Not specified
Organism: Not specified
Investigations: Demonstration ISA
Studies: Example Study
Assays: Example Modelling Analysis